2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. Discoidin Domain Receptor

Discoidin Domain Receptor

Discoidin Domain Receptor

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Discoidin domain receptors (DDRs) are members of the transmembrane receptor tyrosine kinase (RTK) superfamily which are distinguished from others by the presence of a discoidin motif in the extracellular domain and their utilization of collagens as internal ligands. Two types of DDRs, DDR1 and DDR2, have been identified with distinct expression profiles and ligand specificities.

Upon collagen binding, DDRs transduce cellular signaling involved in various cell functions, including cell adhesion, proliferation, differentiation, migration, and matrix homeostasis. Altered DDR function resulting from either mutations or overexpression has been implicated in several types of disease, including atherosclerosis, inflammation, cancer, and tissue fibrosis. DDRs have been considered as novel potential molecular targets for drug discovery and increasing efforts are being devoted to the identification of new small molecule inhibitors targeting the receptors.

Discoidin Domain Receptor Isoform Specific Products:

Discoidin Domain Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101034
    CHMFL-ABL/KIT-155
    CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s of 46 nM and 75 nM, respectively), and it also presents significant inhibitory activities to BLK (IC50=81 nM), CSF1R (IC50=227 nM), DDR1 (IC50=116 nM), DDR2 (IC50=325 nM), LCK (IC50=12 nM) and PDGFRβ (IC50=80 nM) kinases. CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155) arrests cell cycle progression and induces apoptosis.
    CHMFL-ABL/KIT-155
  • HY-13979A
    DDR1-IN-1 dihydrochloride
    		Inhibitor
    DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM).
    DDR1-IN-1 dihydrochloride
  • HY-RS03624
    Ddr2 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ddr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ddr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ddr2 Mouse Pre-designed siRNA Set A
    Ddr2 Mouse Pre-designed siRNA Set A
  • HY-P990400
    Anti-DDR1/CD167a Antibody
    		Inhibitor
    Anti-DDR1/CD167a Antibody is a CHO-expressed human antibody that targets DDR1/CD167a. The Anti-DDR1/CD167a Antibody has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-DDR1/CD167a Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-DDR1/CD167a Antibody
  • HY-162540
    LLC355
    		Degrader
    LLC355 is a discoidin domain receptor 1 (DDR1) ATTEC degrader. LLC355 efficiently degrades DDR1 protein with a DC50 value of 150.8 nM in non-small cell lung cancer NCI-H23 cells. LLC355 induces DDR1 degradation via lysosome-mediated autophagy. LLC355 potently inhibits cancer cell tumorigenicity, migration, and invasion.
    LLC355
  • HY-14979A
    ML786 dihydrochloride
    		Inhibitor
    ML786 dihydrochloride is a potent and orally bioavailable Raf inhibitor, with IC50s of 2.1, 4.2, and 2.5 nM for V600EΔB-Raf, wt B-Raf, and C-Raf, respectively. ML786 dihydrochloride also inhibits Abl-1, DDR2, EPHA2, VEGFR2/KDR/Flk-1, and RET (IC50=<0.5, 7.0, 11, 6.2, 0.8 nM). ML786 dihydrochloride can be used for the research of cancers.
    ML786 dihydrochloride
  • HY-RS03621
    Ddr1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ddr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ddr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ddr1 Mouse Pre-designed siRNA Set A
    Ddr1 Mouse Pre-designed siRNA Set A
  • HY-RS03623
    DDR2 Human Pre-designed siRNA Set A
    		Inhibitor

    DDR2 Human Pre-designed siRNA Set A contains three designed siRNAs for DDR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    DDR2 Human Pre-designed siRNA Set A
    DDR2 Human Pre-designed siRNA Set A
  • HY-NP131
    Recombinant Humanized Type III Collagen (30-40kDa)
    		Activator
    Recombinant Humanized Type III Collagen 30-40kDa is a novel biomaterial that have anticancer effects. Recombinant Humanized Type III Collagen 30-40kDa activates discoidin domain receptor 1 (DDR1), and thus inhibits autophagy, proliferation, and migration of cancer cells, and induces apoptosis.
    Recombinant Humanized Type III Collagen (30-40kDa)
  • HY-160689
    GW694590A
    		Inhibitor
    GW694590A (UNC10112731) is a MYC protein stabilizer that increases endogenous MYC protein levels. GW694590A also targets receptor tyrosine kinases, inhibiting DDR2, KIT and PDGFRα by 81% at 1 μM. , 68% and 67%. GW694590A is a protein kinase inhibitor across ATP-dependent and -independent luciferases with potential effects on the Fluc reporter gene.
    GW694590A
  • HY-RS03620
    DDR1 Human Pre-designed siRNA Set A
    		Inhibitor

    DDR1 Human Pre-designed siRNA Set A contains three designed siRNAs for DDR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    DDR1 Human Pre-designed siRNA Set A
    DDR1 Human Pre-designed siRNA Set A
  • HY-167745
    DDR1-IN-9
    		Inhibitor
    DDR1-IN-9 is a selective inhibitor of DDR1 with significant kinase activity suppression, exhibiting a Kd value of 4.7 nM and an IC50 value of 9.4 nM. DDR1-IN-9 demonstrates reduced potency against a diverse panel of 400 nonmutated kinases, indicating its specificity. Additionally, DDR1-IN-9 shows favorable pharmacokinetic properties and potential therapeutic effects in a model of pulmonary fibrosis.
    DDR1-IN-9
  • HY-150552
    JNK3 inhibitor-2
    JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor with IC50 values of >100, >100, 0.25 µM for JNK1, JNK2, JNK3, respectively. JNK3 inhibitor-2 shows DDR1 and EGFR (T790M, L858R) inhibition.
    JNK3 inhibitor-2
  • HY-162102
    DDR1-IN-8
    		Inhibitor
    DDR1-IN-8 (compound 7s) is a potent inhibitor of DDR1/2, with the IC50 values of 0.045 μM and 0.126 μM, respectively. DDR1-IN-8 has anti-tumor activity.
    DDR1-IN-8
  • HY-122848
    DDR1/2 inhibitor-3
    		Inhibitor
    DDR1/2 inhibitor-3 (5n) is a DDR1/2 inhibitor, with IC50 values​of 9.4 and 20.4 nM, respectively. DDR1/2 inhibitor-3 can be used in anti-inflammatory research.
    DDR1/2 inhibitor-3
  • HY-W778154
    O,O-Dimethyl dithiophosphate-13C2 ammonium
    		Inhibitor
    O,O-Dimethyl dithiophosphate-13C2 (ammonium) is the 13C labeled isotope of O,O-Dimethyl dithiophosphate-13C2 (ammonium).
    O,O-Dimethyl dithiophosphate-<sup>13</sup>C<sub>2</sub> ammonium
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Discoidin Domain Receptor Isoform Comparison

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